This study employs a novel drug targeting technology DART(drug acutely restricted by tethering), to selectively block GABAA receptors on VTADA neurons as mice engage in Pavlovian learning.
Thalamic input can trigger dopamine release in the striatum during motor learning, likely reflecting action vigor rather than motor error. Changes in this mode of dopamine release may contribute to motor and non-motor symptoms of PD.
This is the primary dataset for the article by Miller-Hansen et al "Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum"
