This study employs a novel drug targeting technology DART(drug acutely restricted by tethering), to selectively block GABAA receptors on VTADA neurons as mice engage in Pavlovian learning.
This protocol details the experimental procedures on animals that includes the surgery, two-photon imaging, cued lever-pushing task and analysis includes movement behavior analysis, and PCA.
This dataset contains raw two photon images, and calcium trace and behavior data from the paper Sheng et al 2025 "Activity-Dependent Remodeling of Corticostriatal Axonal Boutons During Motor Learning”.
