Genome-wide association identified novel etiological insights associated with Parkinson’s disease in African and African admixed populations

By Mie Rizig, Sara Bandres-Ciga, Mary B Makarious, Oluwadamilola Ojo , Peter Wild Crea, Oladunni Abiodun, Kristin S Levine, Sani Abubakar, Charles Achoru, Dan Vitale, Olaleye Adeniji, Osigwe Agabi, Mathew J Koretsky, Uchechi Agulanna, Deborah Hall, Rufus Akinyemi, Tao Xie, Mohammed Ali, Ejaz A Shamim, Ifeyinwa Ani-Osheku, Mahesh Padmanaban, Owotemu Arigboki, David Standaert, Abiodun Bello, Marissa Dean, Cyril Erameh, Inas Elsayed, Temitope Farombi, Olaitan Okunoye, Michael Fawale, Kimberley J Billingsley, Frank Imarhiagbe, Pilar Alvarez Jerez, Emmanuel Iwuozo, Breeana Baker, Borenikeji Komolafe, Laksh Malik, Paul Nwani, Kensuke Daida, Ernest Nwazor, Abigail Miano-Burkhardt, Yakub Nyandaiti, Zih-Hua Fang, Yahaya Obiabo, Jillian H Kluss, Olanidi Odeniyi, Dena Hernandez, Francis Odiase, Nahid Tayebi, Francis Ojini, Ellen Sidranksy, Gerald Onwuegbuzie, Andrea M'DSouza, Godwin Osaigbovo, Bahafta Berhe, Nosakhare Osemwegie, Xylena Reed, Olajumoke Oshinaike, Hampton Leonard, Folajimi Otubogun, Chelsea X Alvarado, Shyngle Oyakhire, Simon Ozomma, Sarah Samuel, Funmilola Taiwo, Kolawole Wahab, Yusuf Zubair, Hirotaka Iwake, Jonggeol Jeffrey Kim, Huw Morris, John Hardy, Mike Nalls, Karl Heilbron and Lucy Norcliffe-Kaufmann
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Output Details

Description
Understanding the genetic mechanisms underlying diseases in ancestrally diverse populations is a critical step towards the realization of the global application of precision medicine. Here we perform a comprehensive genome-wide assessment of Parkinson’s disease (PD) in African and African admixed ancestry, characterizing population-specific risk, differential haplotype structure and admixture, coding and structural genetic variation and polygenic risk profiling. We identified a novel common risk factor for PD and age at onset at the GBA1 locus, that was found to be rare in non-African/African admixed populations.
Identifier (DOI)
10.1101/2023.05.05.23289529
Tags
  • GWAS
  • Parkinson's disease
Program
Global Parkinson's Genetics Program

Meet the Authors

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    Mie Rizig

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    Sara Bandres-Ciga

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    Mary B Makarious

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    Oluwadamilola Ojo

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    Peter Wild Crea

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    Oladunni Abiodun

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    Kristin S Levine

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    Sani Abubakar

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    Charles Achoru

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    Dan Vitale

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    Olaleye Adeniji

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    Osigwe Agabi

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    Mathew J Koretsky

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    Uchechi Agulanna

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    Deborah Hall

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    Rufus Akinyemi

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    Tao Xie

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    Mohammed Ali

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    Ejaz A Shamim

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    Ifeyinwa Ani-Osheku

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    Mahesh Padmanaban

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    Owotemu Arigboki

  • David Standaert

    Key Personnel: Team Sulzer, 

    University of Alabama at Birmingham

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    Abiodun Bello

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    Marissa Dean

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    Cyril Erameh

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    Inas Elsayed

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    Temitope Farombi

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    Olaitan Okunoye

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    Michael Fawale

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    Kimberley J Billingsley

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    Frank Imarhiagbe

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    Pilar Alvarez Jerez

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    Emmanuel Iwuozo

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    Breeana Baker

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    Borenikeji Komolafe

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    Laksh Malik

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    Paul Nwani

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    Kensuke Daida

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    Ernest Nwazor

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    Abigail Miano-Burkhardt

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    Yakub Nyandaiti

  • User avatar fallback logo

    Zih-Hua Fang

  • User avatar fallback logo

    Yahaya Obiabo

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    Jillian H Kluss

  • User avatar fallback logo

    Olanidi Odeniyi

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    Dena Hernandez

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    Francis Odiase

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    Nahid Tayebi

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    Francis Ojini

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    Ellen Sidranksy

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    Gerald Onwuegbuzie

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    Andrea M'DSouza

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    Godwin Osaigbovo

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    Bahafta Berhe

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    Nosakhare Osemwegie

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    Xylena Reed

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    Olajumoke Oshinaike

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    Hampton Leonard

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    Folajimi Otubogun

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    Chelsea X Alvarado

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    Shyngle Oyakhire

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    Simon Ozomma

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    Sarah Samuel

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    Funmilola Taiwo

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    Kolawole Wahab

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    Yusuf Zubair

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    Hirotaka Iwake

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    Jonggeol Jeffrey Kim

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    Huw Morris

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    John Hardy

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    Mike Nalls

  • User avatar fallback logo

    Karl Heilbron

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    Lucy Norcliffe-Kaufmann

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