H9 ES AAVS-NGN2; FBXO7-/-
Output Details
- Human
- Mitophagy
Meet the Authors
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Jiuchun Zhang
External Collaborator
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Related Research
PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
PINK1 and Parkin promote damaged mitochondria removal through Ub phosphorylation, Parkin activation. FBXO7 mutation in PD may not affect mitophagy in HeLa and neuron cells, suggesting it may not play a significant role in Parkin-dependent mitophagy.
Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation
This study used neuroimaging to show a ventral putamen-centered open-loop circuit linking emotions and movement in humans. Contextual incentives influence which motor circuit is activated, shedding light on paradoxical kinesia in Parkinson's Disease.
Neural Control of Autonomic Arousal During Threat Anticipation Revealed by High-Resolution Cardiac Contractility
These findings highlight neural correlates of adaptive behavioral mobilization during emotion-guided action, shedding light on motor circuitry that may be engaged during paradoxical kinesia, a phenomenon of emotion-relevant motor facilitation in PD.