H9 ES AAVS-NGN2; FBXO7-/-
Output Details
Description
H9 ES cells with AAVS1-NGN2 in which FBXO7 has been deleted using CRISPR
Tags
- Human
- Mitophagy
Meet the Authors
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Jiuchun Zhang
External Collaborator
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Related Research
PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
PINK1 and Parkin promote damaged mitochondria removal through Ub phosphorylation, Parkin activation. FBXO7 mutation in PD may not affect mitophagy in HeLa and neuron cells, suggesting it may not play a significant role in Parkin-dependent mitophagy.
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