HeLa HFT/TO PARK2 FBXO7−/−
Output Details
- Human
- Mitophagy
Meet the Authors
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Jiuchun Zhang
External Collaborator
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Related Research
PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
PINK1 and Parkin promote damaged mitochondria removal through Ub phosphorylation, Parkin activation. FBXO7 mutation in PD may not affect mitophagy in HeLa and neuron cells, suggesting it may not play a significant role in Parkin-dependent mitophagy.
Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation
This study used neuroimaging to show a ventral putamen-centered open-loop circuit linking emotions and movement in humans. Contextual incentives influence which motor circuit is activated, shedding light on paradoxical kinesia in Parkinson's Disease.
Integrated Representations of Threat and Controllability in the Lateral Frontal Pole
Emotions can strongly influence behavior, as seen in PD paradoxical kinesia. Here, we demonstrate that anticipating threats enhances motor accuracy through interactions between the amygdala and the anterior pole of the lateral prefrontal cortex.