This study employs a novel drug targeting technology DART(drug acutely restricted by tethering), to selectively block GABAA receptors on VTADA neurons as mice engage in Pavlovian learning.
We identify 125 functional risk genes for 50 loci—nearly doubling supported genes—and assign genes and cell types to over half of GWAS signals. Unexpectedly, 51% of risk genes are regulated in glia, particularly oligodendrocytes and their…
Guide for analyzing for analysis of synaptic loci density and pre- and postsynaptic volumes (SynDOVE). from confocal images of pre- and postsynaptic loci in fixed brain sections with Imaris software.
