Image Dataset: Molecular Analysis of Network Vulnerability to α-Synuclein Pathology and PAKs as Therapeutic Targets in Parkinson’s Disease
Output Details
Description
This dataset includes all immunofluorescence images associated with the publication referenced here: DOI: [10.1101/2024.10.22.619411]. In this study, full brain α-synuclein pathology was mapped in mice over 9 months. Empirical pathology data was compared to theoretical pathology estimates from a diffusion model of pathology progression along anatomical connections. Unexplained variance in the model enabled us to derive regional vulnerability that we compared to regional gene expression. We identified gene expression patterns that relate to regional vulnerability, including 12 kinases that were enriched in vulnerable regions. Among these, an inhibitor of group II PAKs demonstrated protection from neuron death and α-synuclein pathology. The dataset also comprises immunofluorescence images from both mouse brain tissue and primary hippocampal neurons.
Identifier (DOI)
10.35077/g.1178
