The bridge-like lipid transfer protein, BLTP3A/UHRF1BP1, anchors VAMP7-positive vesicles to lysosomes and acts as an effector of CASM potentially to aid in the repair or mitigation of lysosomal damage.
A PD-linked mutation in Synaptojanin 1 causes abnormal plasma membrane infoldings in specific dopaminergic axons, associated with reduced dopamine release, suggesting an imbalance in exocytosis and endocytosis.
