LBD-case-case-GWAS

Code used in article: Investigation of the genetic aetiology of Lewy body diseases with and without dementia. A discrete phenotype genome-wide association study was conducted comparing Lewy body diseases with and without dementia to decode disease heterogeneity by investigating the genetic drivers of dementia in Lewy body diseases. It was found that risk allele rs429358 tagging APOEe4 increases the odds of developing dementia, and that rs7668531 near the MMRN1 and SNCA-AS1 genes and an intronic variant rs17442721 tagging LRRK2 G2019S on chromosome 12 are protective against dementia.