Mitochondrial Proteostasis Cryo-ET Analysis
Output Details
Description
Using cryo–electron tomography in human cells, we investigated the structural response of mitochondria to proteostatic stress. Stress induced protein aggregation in the mitochondrial matrix, remodeling of cristae architecture, and a reduction in mitochondrial ribosome complexes. Concomitantly, mitochondrial Hsp60 adopted conformations favoring complexes with its co-chaperone Hsp10, revealing structural adaptations that support mitochondrial proteostasis.
Identifier (DOI)
10.5281/zenodo.17292570
