Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons

Description

In this study, Hwang, Roth, et al. find that motor learning recruits a population of engram neurons in the motor cortex that are reactivated during task performance. Motor learning leads to selective remodeling of dendritic spines and strengthening of outputs to the striatum of M1 engram neurons.

Identifier (DOI)

10.1016/j.neuron.2022.06.006

Tags

Cortical
Motor symptoms
Original Research
Striatum

Discovery Team

Team Surmeier

Program

Collaborative Research Network

Theme

Circuitry and Brain-Body Interactions

Meet the Authors

Fuu Jiun Hwang

External Collaborator
Richard Roth

External Collaborator
Yu-Wei Wu

External Collaborator
Yue Sun

External Collaborator
Destany K. Kwon

External Collaborator
Yu Liu

External Collaborator
Jun Ding

External Collaborator

Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons

Output Details

Meet the Authors

Fuu Jiun Hwang

Richard Roth

Yu-Wei Wu

Yue Sun

Destany K. Kwon

Yu Liu

Jun Ding

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Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons Dataset

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Datasets and Key Resources Table used in Do, Quyen B. et al. (2023) “Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson’s GBA-N370S mutation”