NEURON + Python model of striatal projection neurons for Belal et al. 'Cholinergic interneuron control of GABAergic circuits targeting spiny projection neurons is disrupted in parkinsonian models'

Description

This repository is intended to reproduce the model simulations and figure-generation workflows associated with the manuscript. Initial public release of the model code and documentation for the Belal et al. 2026 study.

Identifier (DOI)

10.5281/zenodo.20705696

Tags

Computer modeling
Spiny projection neurons
Striatum

Discovery Team

Team Surmeier

Program

Collaborative Research Network

Theme

Circuitry and Brain-Body Interactions

Meet the Authors

Vernon Clarke

External Collaborator
James Surmeier, PhD

Lead PI (Core Leadership): Team Surmeier, Team Awatramani, Team Dombeck,

Northwestern University

NEURON + Python model of striatal projection neurons for Belal et al. ‘Cholinergic interneuron control of GABAergic circuits targeting spiny projection neurons is disrupted in parkinsonian models’

Output Details

Meet the Authors

Vernon Clarke

James Surmeier, PhD

Related Research

Code for a-synuclein spread: Molecular analysis of network vulnerability to α-synuclein pathology reveals PAKs as therapeutic targets for Parkinson’s disease

Simulations predict differing phase responses to excitation vs. inhibition intheta-resonant pyramidal neurons

State-dependent GABAergic regulation of striatal spiny projection neuron excitability: NEURON + Python model of striatal projection neurons