Cre-dependent expression of human tyrosinase induces the formation of neuromelanin in catecholaminergic neurons. The CbH promoter is a strong, pan-neuronal, non-silencable promoter.
Viral Vector: Two rhesus macaque animals were tested for AAVrg-hSyn-mCherry in the spinal cord. The authors observed abundant mCherry-positive neurons in expected targets (i.e., motor cortical regions known to project to the spinal cord).
Two rhesus macaques were tested with AAVrg-hSyn-mCherry in the putamen, showing numerous mCherry-positive neurons in motor cortical regions projecting to the putamen.
