The endoplasmic reticulum (ER) is crucial for various cellular functions. ER proteome is modified by autophagy, especially in neurons. Specific receptors target ER components for degradation, impacting neuronal health.
The PD5D Atlas deciphers Parkinson's disease molecular blueprint using brain space, disease stage, and cell types dimensions. It includes various omics data and clinical scales to analyze PD progression from healthy aging to Lewy body neuropathology.
Allele-specific expression (ASE) analysis in single-nucleus RNA-seq (snRNA-Seq) helps study genetic variation impact on RNA expression. Experimental and computational choices can enhance ASE analysis results.
