Authors determine cryo-EM structure of human ULK1C core and its complex with PI3KC3-C1. ULK1C core undergoes a rearrangement from 2:1:1 to 2:2:2 stoichiometry, suggesting a structural mechanism for autophagy initiation.
The PD5D Atlas deciphers Parkinson's disease molecular blueprint using brain space, disease stage, and cell types dimensions. It includes various omics data and clinical scales to analyze PD progression from healthy aging to Lewy body neuropathology.
Allele-specific expression (ASE) analysis in single-nucleus RNA-seq (snRNA-Seq) helps study genetic variation impact on RNA expression. Experimental and computational choices can enhance ASE analysis results.
