pFB-hSyn-DIO-saCAS-minWPRE

Research Community
Research Community

ASAP supports three programs and serves as a member of multiple consortia to advance research for the benefit of the global Parkinson’s disease community.
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Highlights

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Open Science
Open Science

ASAP is dedicated to facilitating a research environment where meaningful collaboration, research-enabling resources, and data sharing provides the answers we need to understand, diagnose, and treat Parkinson’s disease. Discover our open science philosophy.
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Tools & Resources

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Description

CRISPR-SaCas9 for in vivo genome editing. Used to locate and cleave specific double-stranded DNA sequences. Used as a co-injection material to delete M1R, in an alternative assay for the therapeutic effect of levodopa by examining the impact of M1R deletion in a bilateral, genetic model of PD.

Tags

AAV (Adenoassociated Virus)
CRISPR

Discovery Team

Team Surmeier

Program

Collaborative Research Network

Theme

Circuitry and Brain-Body Interactions

pFB-hSyn-DIO-saCAS-minWPRE

Output Details

Related Research

State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson’s disease

pFB-hSyn-SaCas9-mWPRE-hGHpA

pAAV-hSyn-FRed-U6gRsGABAd-a4