Aligning Science Across Parkinson's Logo Text

pMX-Flag-GFP_SlC45A1 mutant p.Arg210Trp

Output Details

Description
GFP-SLC45A1 plasmid with p.Arg210Trp mutation
Discovery Team
Team Alessi
Program
Collaborative Research Network
Theme
PD Functional Genomics

Related Research

Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

A study identified new lysosomal proteins in brain cells, including SLC45A1, linked to a neurological disease. Loss of SLC45A1 disrupts lysosomal function, impacting V-ATPase stability and causing mitochondrial dysfunction.

View Article

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress

Cryo-ET showed protein aggregates, altered cristae, and reduced ribosome complexes in stressed mitochondria. Mitochondrial Hsp60 undergoes conformational changes to aid in protein folding, shedding light on mitochondrial proteostasis mechanisms.

View Article

Selective loss of Primary Cilia and Neurotrophic Signaling in G51D α-Synuclein Mice Highlights a Common Pathway to Parkinson’s Disease

G51D α-synuclein mice mimic disease symptoms, showing cilia loss in specific neurons and impaired neurotrophic signaling, contributing to disease progression. This highlights the role of ciliary dysfunction in Parkinson’s.

View Article
View More Outputs
Aligning Science Across Parkinson's
Powered by  GDPR Cookie Compliance (opens in a new tab)
Privacy Overview

This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.