Polyamines are crucial for brain function. ATP13A4 is the main polyamine transporter in astrocytes, impacting astrocyte morphology, synapse formation, and neurodevelopment. Mutations in ATP13A4 are linked to neurodevelopmental disorders.
Here you can find the Key resource table realted to the publication: Bukhari et al., 2024 Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model.
LRRK2-G2019S affects iron homeostasis in macrophages by dysregulating iron-related proteins. This leads to impaired ferritinophagy, increased oxidative stress, and cell death, highlighting LRRK2's role in iron regulation in Parkinson's Disease.
