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Protein interaction network analysis for Mendelian diseases

By Nikoleta Vavouraki, James Tomkins, PhD, Eleanna Kara, Henry Houlden, John Hardy, PhD, Marcus J. Tindal, Patrick Lewis, PhD and Claudia Manzoni, PhD
View Published Protocol

Output Details

Description

This protocol describes the steps to use experimentally validated human data to create a protein-protein interaction network (PPIN) based on disease causative genes. Network analysis (combination of topological functional analyses) will lead to the identification of biological processes relevant for disease and disease endophenotypes.

Identifier (DOI)
10.17504/protocols.io.buwanxae
Tags
  • Phenotypic variability
  • Protein-protein interaction
Team
Team Hardy
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

  • User avatar fallback logo

    Nikoleta Vavouraki

    External Collaborator

  • James Tomkins, PhD

    Key Personnel: Team Wood, 

    University of Cambridge

  • User avatar fallback logo

    Eleanna Kara

    External Collaborator

  • User avatar fallback logo

    Henry Houlden

    External Collaborator

  • John Hardy, PhD

    Lead PI (Core Leadership): Team Hardy, 

    University College London

  • User avatar fallback logo

    Marcus J. Tindal

    External Collaborator

  • Patrick Lewis, PhD

    Collaborating PI: Team Hardy, 

    Royal Veterinary College

  • Claudia Manzoni, PhD

    Key Personnel: Team Hardy, 

    University College London

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Aligning Science Across Parkinson's
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