We combined single-nucleus multi-omic sequencing and high-plex spatial transcriptomics to build a comprehensive atlas of medium spiny neurons (MSNs) across the entire macaque striatum, revealing new MSN subtypes and their association with diseases.
This protocol details standard operating procedure (SOP) for systemic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in non-human primates.
Modern neuroscience approaches including optogenetics, calcium imaging, and other genetic manipulations have facilitated our ability to dissect specific circuits in rodent models to study their role in neurological disease. These approaches…
