Reach-related Single Unit Activity in the Parkinsonian Macaque

This dataset contains recordings of single-unit activity from multiple brain areas, including globus pallidus-internus (GPi), ventrolateral nucleus of the thalamus (VLa and VLp), and the arm-related regions of the primary motor cortex, including sulcus (M1-S) and gyrus (M1-G) subregions, in monkeys performing a choice reaction time reaching task. Small numbers of recordings were also obtained from the supplementary motor area (SMA), external globus pallidus (GPe), the thalamic reticular nucleus (RTN), striatum (STR), and the region between RTN and VL thalamus (R-V). It contains data from two monkeys before and after the administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), which induces Parkinsonism. The neuronal activity was recorded using 16-contact linear probes (0.5–1.0 MΩ, V-probe, Plexon) or glass-insulated tungsten microelectrodes (0.5–1.5 MΩ, Alpha Omega). The neuronal data were amplified (4×, 2 Hz–7.5 kHz) and digitized at 24.414 kHz (approx., 16-bit resolution; Tucker Davis Technologies). The neuronal data were high-pass filtered (Fpass: 200 Hz, Matlab FIRPM) and thresholded, and candidate action potentials were sorted into clusters in principal components space (Off-line Sorter, Plexon or custom algorithm, TomSort, https://zenodo.org/doi/10.5281/zenodo.11176978). The recordings for subject Isis before the administration of MPTP (pre-MPTP) were collected by Daisuke Kase. The recordings for subject Isis after the administration of MPTP (post-MPTP) were collected by Yan Han (韩妍). The recordings for subject Gaia (pre-MPTP, post-MPTP) from 2015 were collected by Andrew J. Zimnik. The recordings for subject Gaia (post-MPTP) from 2016-2017 were also collected by Daisuke Kase.