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Exploring the relationship between GBA1 host genotype and gut microbiome in the GBA1L444P/WT mouse model: Implications for Parkinson disease pathogenesis

Heterozygous *GBA1* variants are common in Parkinson's disease. This study found no significant impact of the *GBA1* L444P variant on gut microbiome composition in mice, suggesting other factors may contribute to disease penetrance.

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Bolen Human Sigmoid Colon RNA CosMx Dataset

NanoString CosMx RNA dataset from human sigmoid colon of healthy controls, Parkinson's Disease, or inflammatory bowel disease exported for analysis.

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Metagenomics sequencing data of publication doi.org/10.3389/fnins.2025.1546203

The study explores the connection between *GBA1* gene variants and gut microbiome in a mouse model, shedding light on Parkinson's disease development.

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Read Alignment table associated with doi.org/10.3389/fnins.2025.1546203

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Exploring the relationship between GBA1 host genotype and gut microbiome in the GBA1L444P/WT mouse model: Implications for Parkinson disease pathogenesis

Bolen Human Sigmoid Colon RNA CosMx Dataset

Metagenomics sequencing data of publication doi.org/10.3389/fnins.2025.1546203