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Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease: Bioinformatic Prioritisation and Hit Validation

By Karishma D'Sa, Sebastian Guelfi, David Zhang, Alan Pittman, Daniah Trabzuni, Demis A. Kia, Nicholas W Wood, John Hardy, PhD, Claudia Manzoni, Mina Ryten, Benjamin O'Callaghan
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Output Details

Description
This protocol describes the Bioinformatic Prioritisation of PD GWAS candidates for High Content Screening, and Hit Validation by allele-specific expression (ASE) analysis.
Identifier (DOI)
10.1101/2020.01.06.896241v2
Tags
  • High Content Screening
  • Parkinson's disease
  • Substantia nigra
Discovery Team
Team Wood, Team Hardy
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

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    Karishma D'Sa

    External Collaborator

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    Sebastian Guelfi

    External Collaborator

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    David Zhang

    External Collaborator

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    Alan Pittman

    External Collaborator

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    Daniah Trabzuni

    External Collaborator

  • User avatar fallback logo

    Demis A. Kia

    External Collaborator

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    Nicholas W Wood

    External Collaborator

  • John Hardy, PhD

    Lead PI (Core Leadership): Team Hardy, 

    University College London

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    Claudia Manzoni

    External Collaborator

  • Mina Ryten

    Co-PI (Core Leadership): Team Hardy,  Team Wood, 

    University College London

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    Benjamin O'Callaghan

    External Collaborator

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Aligning Science Across Parkinson's
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