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Single particle analysis datasets of in vitro grown aSyn filaments

By Kevin Sicking, Mohammed Al-Azzani, Tiago F. Outeiro and Ruben Fernandez-Busnadiego, PhD
View Published Dataset

Output Details

Description
Raw single particle cryo-EM micrographs of recombinant a-Synuclein fibrils. The dataset contains WT data, as well as images of fibrils carrying two a-Synuclein mutations (G14R and K58N) recently discovered in patients.
Identifier (DOI)
10.1101/2024.09.23.24313864
Tags
  • Cryo-EM
  • In Vitro
  • Microscopy - electron
Team
Team Harper
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

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Single particle analysis of α-Synuclein fibrils

Aggregates of α-Synuclein are linked to Parkinson’s, multiple system atrophy, and Lewy body dementia. This protocol outlines near-atomic resolution structures of these amyloid fibrils using cryo-EM single particle analysis.

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Cryo-EM map of in vitro grown G14R alpha-synuclein fibrils

3.0 A resolution cryo-EM map obtained from recombinant a-synuclein fibrils carrying the G14R mutation recently discovered in a patient of a complex neurological disease.

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Cryo-EM map of in vitro grown WT alpha-synuclein fibrils

Cryo-EM density map of recombinant WT a-synuclein fibrils at 2.7 A resolution.

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Aligning Science Across Parkinson's
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