Cells maintain optimal levels of lysosome degradative activity to protect against pathogens, clear waste, and generate nutrients. Here, we show that LRRK2, a protein that is tightly linked to Parkinson’s disease, negatively regulates lysosome…
A PD-linked mutation in Synaptojanin 1 causes abnormal plasma membrane infoldings in specific dopaminergic axons, associated with reduced dopamine release, suggesting an imbalance in exocytosis and endocytosis.
