suny-downstate-medical-center/pd_m1_6ohda: M1_Control_6OHDA

Pyramidal tract neurons are the most direct output to muscles from the primary motor cortex (M1). Liqiang Chu et al (2021: https://www.jneurosci.org/content/41/25/5553) have shown that layer 5 pyramidal tract neurons (PT5B) decrease in excitability in Parkinsonian as compared with control M1 in mice treated with 6-OHDA. We built this simulation, based on a detailed motor cortex implementation in NetPyNE ([http://doc.netpyne.org/](http://doc.netpyne.org/)), to see how the changed PT5B neuron excitability changes M1 spiking dynamics.