Using microfluidic diffusional sizing, the authors show that the molecular chaperone family Hsp70 (specifically Hsc70, DnaJB, and Apg2) can completely dissolve alpha-synuclein aggregation and revert it back to its monomeric state.
This protocol is associated with the following preprint, published on February 19th 2022:
The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds
Itika Saha, Patricia Yuste-Checa, Miguel Da Silva Padilha, Qiang Guo, Roman…
