Temporal landscape of mitochondrial proteostasis governed by the UPRmt_NGS data_Part 2

By Louise Uoselis, PhD, Runa Lindblom, PhD, Wai Kit (Leo) Lam, PhD, Catharina Küng, Marvin Skulsuppaisarn, Grace Khuu, BSc, Thanh Nguyen, PhD, Danielle L Rudler, Aleksandra Filipovska, Ralf B Schittenhelm and Michael Lazarou, PhD
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Output Details

Description
Part 2 of NGS data associated with Uoselis et al., 2023.
Identifier (DOI)
10.5281/zenodo.8260629
Tags
  • Human
  • non-iPSC cell
Team
Team Hurley
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

  • User avatar fallback logo

    Louise Uoselis, PhD

    Key Personnel: Team Hurley, 

    Walter and Eliza Hall Institute of Medical Research

  • User avatar fallback logo

    Runa Lindblom, PhD

    Key Personnel: Team Hurley, 

    Monash University

  • Wai Kit (Leo) Lam, PhD

    Key Personnel: Team Hurley, 

    Walter and Eliza Hall Institute of Medical Research

  • User avatar fallback logo

    Catharina Küng

  • User avatar fallback logo

    Marvin Skulsuppaisarn

  • User avatar fallback logo

    Grace Khuu, BSc

    Key Personnel: Team Hurley, 

    Monash University

  • Thanh Nguyen, PhD

    Key Personnel: Team Hurley, 

    Walter and Eliza Hall Institute of Medical Research

  • User avatar fallback logo

    Danielle L Rudler

  • User avatar fallback logo

    Aleksandra Filipovska

  • User avatar fallback logo

    Ralf B Schittenhelm

  • Michael Lazarou, PhD

    Co-PI (Core Leadership): Team Hurley, 

    Monash University

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Temporal landscape of mitochondrial proteostasis governed by the UPRmt

The authors developed a functional proteomics framework, termed MitoPQ (Mitochondrial Proteostasis Quantification), to dissect the UPRmts role in maintaining proteostasis during stress.

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L1-silenced iPSC line (HS1_L1HS-CRISPRi_g1)

Human iPSCs were modified with CRISPRi to target LINE-1 retrotransposons, creating stable cell lines with different genetic backgrounds and guide RNAs. These resources are detailed in Adami et al. (DOI: 10.1016/j.xgen.2025.100979).

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L1-silenced iPSC line (HS1_L1HS-CRISPRi_g2 )

Human iPSCs were modified with CRISPRi to target LINE-1 retrotransposons, creating stable cell lines with different genetic backgrounds and guide RNAs. These resources are detailed in Adami et al. (DOI: 10.1016/j.xgen.2025.100979).

View Lab Material
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