Unconventional Initiation of PINK1/Parkin Mitophagy by Optineurin

By Thanh Nguyen, Justyna Sawa-Makarska, Grace Khuu, Wai Kit (Leo) Lam, Elias Adriaenssens, Dorotea Fracchiolla, PhD, Stephen Shoebridge, Benjamin Padman, Marvin Skulsuppaisarn, Runa Lindblom, Sascha Martens, Michael Lazarou, PhD

Published August 12, 2022

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Description

This work reveals that OPTN mitophagy initiation is mechanistically distinct and highlights the mechanistic plasticity of selective autophagy pathways.

Identifier (DOI)

10.1016/j.molcel.2023.04.021

Tags

Cell biology
In Vitro
Mitophagy
Optineurin
Original Research

Discovery Team

Team Hurley

Program

Collaborative Research Network

Theme

PD Functional Genomics

Meet the Authors

Thanh Nguyen

External Collaborator
Justyna Sawa-Makarska

External Collaborator
Grace Khuu

External Collaborator
Wai Kit (Leo) Lam

External Collaborator
Elias Adriaenssens

External Collaborator
Dorotea Fracchiolla, PhD

Project Manager: Team Hurley,

Max Planck Institute of Biophysics
Stephen Shoebridge

External Collaborator
Benjamin Padman

External Collaborator
Marvin Skulsuppaisarn

External Collaborator
Runa Lindblom

External Collaborator
Sascha Martens

Co-PI (Core Leadership): Team Hurley,

Max F. Perutz Laboratories
Michael Lazarou, PhD

Co-PI (Core Leadership): Team Hurley,

Monash University