Unconventional Initiation of PINK1/Parkin Mitophagy by Optineurin

By Thanh Nguyen, PhD, Justyna Sawa-Makarska, PhD, Grace Khuu, BSc, Wai Kit (Leo) Lam, PhD, Elias Adriaenssens, PhD, Dorotea Fracchiolla, PhD, Stephen Shoebridge, MSc, Benjamin Padman, PhD, Marvin Skulsuppaisarn, Runa Lindblom, PhD, Sascha Martens and Michael Lazarou, PhD

Published August 12, 2022

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Description

This work reveals that OPTN mitophagy initiation is mechanistically distinct and highlights the mechanistic plasticity of selective autophagy pathways.

Identifier (DOI)

10.1016/j.molcel.2023.04.021

Tags

Cell biology
In Vitro
Mitophagy
Optineurin
Original Research

Team

Team Hurley

Program

Collaborative Research Network

Theme

PD Functional Genomics

Meet the Authors

Thanh Nguyen, PhD

Key Personnel: Team Hurley,

Walter and Eliza Hall Institute of Medical Research
Justyna Sawa-Makarska, PhD

Key Personnel: Team Hurley,

Max F. Perutz Laboratories
Grace Khuu, BSc

Key Personnel: Team Hurley,

Monash University
Wai Kit (Leo) Lam, PhD

Key Personnel: Team Hurley,

Walter and Eliza Hall Institute of Medical Research
Elias Adriaenssens, PhD

Key Personnel: Team Hurley,

Max F. Perutz Laboratories
Dorotea Fracchiolla, PhD

Project Manager: Team Hurley,

Max Planck Institute of Biophysics
Stephen Shoebridge, MSc

Key Personnel: Team Hurley,

University of Vienna
Benjamin Padman, PhD

Key Personnel: Team Hurley,

Monash University
Marvin Skulsuppaisarn

External Collaborator
Runa Lindblom, PhD

Key Personnel: Team Hurley,

Monash University
Sascha Martens

Co-PI (Core Leadership): Team Hurley,

Max F. Perutz Laboratories
Michael Lazarou, PhD

Co-PI (Core Leadership): Team Hurley,

Monash University