A PD-linked mutation in Synaptojanin 1 causes abnormal plasma membrane infoldings in specific dopaminergic axons, associated with reduced dopamine release, suggesting an imbalance in exocytosis and endocytosis.
LRRK2, linked to Parkinson's disease, responds to lysosomal stress through distinct mechanisms involving lipidation of GABARAP and/or accumulation of Rabs on lysosomes. Understanding these pathways can shed light on Parkinson's disease pathogenesis.
