Whole proteome copy number dataset in primary mouse cortical neurons

Description

The functional diversity of neurons is specified through their proteome resulting in elaborate and tightly regulated protein interaction networks and signalling that regulates neuronal processes. Dysregulation of these dynamic networks in development or in adulthood lead to neurodevelopmental or neurological disorders respectively. Over the past few decades, mass spectrometry has become a powerful tool for quantifying and resolving any proteome, including complex tissues such as the brain proteome, with technological advances leading to higher levels of resolution and throughput than traditional biochemical techniques. In this article, we provide a proteomic reference dataset that has been generated to identify proteins and quantify their level of expression in primary mouse cortical neurons. It represents a summary analysis of previously published data in (Antico et al., 2021).

Identifier (DOI)

10.1016/j.dib.2023.109336

Tags

Brief Communication

Team

Team Alessi

Program

Collaborative Research Network

Theme

PD Functional Genomics

Meet the Authors

Odetta Antico

Key Personnel: Team Alessi,

MRC Protein Phosphorylation and Ubiquitylation Unit
Raja Sekhar Nirujogi, PhD

Key Personnel: Team Alessi,

University of Dundee
Miratul Muqit

Co-PI (Core Leadership): Team Alessi,

University of Dundee

Whole proteome copy number dataset in primary mouse cortical neurons

Output Details

Meet the Authors

Odetta Antico

Raja Sekhar Nirujogi, PhD

Miratul Muqit

Related Research

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK

Primary data associated with the manuscript “Whole proteome copy number dataset in primary mouse cortical neurons” (doi: 10.1016/j.dib.2023.109336)

Black and African American Connections to Parkinson’s Disease Study: Addressing Missing Diversity in Parkinson’s Disease Genetics