Dr. Harper is the Chair of the Department of Cell Biology at Harvard Medical School. His work focuses on the functions, mechanisms and targets of cullin-RING ubiquitin ligases. His recent work has led to the discovery of a phosphorylation-driven feed-forward ubiquitylation pathway controlling PARKIN-dependent mitophagy, and a molecular understanding of the pathways controlling selective autophagy. Dr. Harper has employed interaction proteomics to define interactions and complexes for more than 10,000 human proteins, providing numerous complexes linked to biological pathways. Awards include the Javits Neuroscience award, and election to the American Academy of Arts and Sciences.
Lead PI (Core Leadership)
J. Wade Harper
Harvard University
Dr. Harper is the Chair of the Department of Cell Biology at Harvard Medical School. His work focuses on the functions, mechanisms and targets of cullin-RING ubiquitin ligases. His recent work has led to the discovery of a phosphorylation-driven feed-forward ubiquitylation pathway controlling PARKIN-dependent mitophagy, and a molecular understanding of the pathways controlling selective autophagy. Dr. Harper has employed interaction proteomics to define interactions and complexes for more than 10,000 human proteins, providing numerous complexes linked to biological pathways. Awards include the Javits Neuroscience award, and election to the American Academy of Arts and Sciences.
