Generation of the iPSC line FINi002-A from a male Parkinson’s disease patient carrying compound heterozygous mutations in the PRKN gene
Published October 16, 2023
Output Details
Published October 16, 2023
Description
Generation of the iPSC line FINi002-A from a male Parkinson's disease patient carrying compound heterozygous mutations in the PRKN gene. Primary fibroblasts from a skin biopsy of a male PD patient were reprogrammed using transiently present non-replicating Sendai viruses. We envisage the usefulness of this iPSC line, carrying a common and well-studied missense mutation in the RING1 domain of the PARKIN protein, for the elucidation of PARKIN-dependent mechanisms of PD using in vitro and in vivo models.
Identifier (DOI)
10.1016/j.scr.2023.103211
