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Output Catalog

ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.

  results for "Team Gradinaru"
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Available ASAP-related hPSC collection from Team Studer

Collection of human pluripotent stem cell lines consisting of isogenic GBA, LRRK2, SNCA series, KI-reporter lines for TOMM20, b-actin, LAMB1, LAMP1, a-synuclein overexpression lines, and other hPSC resources.

Program: Collaborative Research Network
Team:
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Collection of protocols of Team Deleidi used in the publication: “”LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease””

Collection of protocols of Team Deleidi used in the publication: ""LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease""

Program: Collaborative Research Network
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Human Postmortem-Derived Brain Sequencing Collection (Harmonized Collection)

The Human Postmortem-derived Brain Sequencing Collection is a harmonized repository comprised of sequencing data contributed by ASAP CRN teams.

Program: Collaborative Research Network
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Evaluating the performance of polygenic risk profiling across diverse ancestry populations in Parkinson’s disease

Objective This study aims to address disparities in risk prediction by evaluating the performance of polygenic risk score (PRS) models using the 90 risk variants across 78 independent loci previously linked to Parkinson’s disease (PD) risk across…

Program: Global Parkinson's Genetics Program
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Multi-ancestry genome-wide meta-analysis in Parkinson’s disease

Although over 90 independent risk variants have been identified for Parkinson’s disease using genome-wide association studies, all studies have been performed in just one population at the time. Here we performed the first large-scale…

Program: Global Parkinson's Genetics Program
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Collection of protocols for paper: “Glucocerebrosidase, a Parkinson´s disease-associated protein, is imported into mitochondria and regulates complex I assembly and function”

This is a collection of protocols used in a recent preprint by the Deleidi Lab, Team Schapira. You can access pre-print at https://doi.org/10.21203/rs.3.rs-1521848/v1

Program: Collaborative Research Network
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Mouse perfusion

Protocol used in the Gradinaru lab for perfusing mice

Program: Collaborative Research Network
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Mouse Open Field

Protocol used in the Gradinaru lab for general locomotion in rodents using open field arenas and Ethovision video tracking

Program: Collaborative Research Network
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Primary Neuron Extraction

Protocol used in the Gradinaru lab to extract primary neurons from mouse on day E17

Program: Collaborative Research Network
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Western Blot with iBind System

Protocol used in the Gradinaru lab for western blot using the iBind Automated Western System

Program: Collaborative Research Network
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Immunostaining Cells

Protocol used in the Gradinaru lab for antibody staining of cells

Program: Collaborative Research Network
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Transfection of HEK cells with Lipofectamine 3000

Protocol used in the Gradinaru lab to transfect HEK cells with lipofectamine 3000

Program: Collaborative Research Network
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Copy of RNA extraction from mouse tissue

Protocol used in the Gradinaru lab for RNA extraction from mouse tissue

Program: Collaborative Research Network
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RNA extraction from organoids

Protocol used in the Gradinaru lab for RNA extraction from organoids

Program: Collaborative Research Network
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Immunostaining Mouse Tissue

Protocol used in the Gradinaru lab for immunohistochemistry to analyze protein expression in the mouse brain

Program: Collaborative Research Network
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