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Catalog
ASAP is committed to accelerating the pace of discovery and informing a path to a cure for Parkinson’s disease through collaboration, research-enabling resources, and data sharing. We’ve created this catalog to showcase the research outputs and tools developed by ASAP-funded programs.
Protocol
Solid phase binding assay – Clusterin binding to very low-density lipoprotein receptor (VLDLR)
This protocol details how to monitor Clusterin binding to the very low-density lipoprotein receptor (VLDLR) by enzyme-linked immunosorbent assays (ELISA) adapted from Leeb et al., 2014.
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Protocol
Analysis of glycosphingolipids from human plasma
The original qualitative method was published in 2004 and measured the oligosaccharides selectively released from glycosphingolipids using a ceramide glycanase enzyme derived from the medicinal leech. This is an updated protocol with the focus on achieving sensitive and reproducible quantitation of glycosphingolipids from human plasma samples
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Article
Immune Senescence, Immunosenescence and Aging
Review: This review focuses on age-related immune dysfunction, cellular senescence and the impaired immune response to pathogens.
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Article
Cellular senescence: a key therapeutic target in aging and diseases
Review: This review discusses the role of SnCs in aging and age-related diseases, strategies to target SnCs, approaches to discover and develop senotherapeutics, and preclinical and clinical advances of senolytics.
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Article
Loss of tau expression attenuates neurodegeneration associated with α-synucleinopathy
Publication: The role of tau in the development of αS pathology and subsequent neuronal dysfunction has been controversial. Herein, the authors examine the role of tau in the onset and progression of αS pathology using a transgenic mouse model of α-synucleinopathy lacking mouse tau expression. View original preprint.
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Open field
This protocol details about Open Field procedure. This protocol details about Open Field procedure.
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Protocol
Intramuscular PFF injection
This protocol details the intramuscular PFF injection procedure. This protocol details the intramuscular PFF injection procedure.
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Protocol
DAB antibody (IHC) staining protocol
This is the basic protocol for antibody staining of formalin fixed paraffin embedded (FFPE) tissue. This is the basic protocol for antibody staining of formalin fixed paraffin embedded (FFPE) tissue.
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