ASAP Collaborative Research Network (CRN) Impact Report
From 2020 to 2024, the ASAP CRN supported 35 multidisciplinary, international teams across 14 countries. See how the CRN has accelerated breakthroughs in PD research through collaboration and open science.
Charting New Waters in Parkinson’s Research: Highlights From the 2025 CRN Collaborative Meeting
ASAP's 2025 Collaborative Meeting welcomed representatives from our 35 CRN teams to share impactful findings on the PD landscape, promote the cross-fertilization of ideas, and provide opportunities to engage the broader CRN across different levels of training.
Dynamic basal ganglia output signals license and suppress forelimb movements
By onBasal ganglia is fundamental to motor control and dysfunction is linked to motor deficits. Our results demonstrate the existence and function of highly specific and temporally precise movement representations in basal ganglia output circuitry.
Mouse Stereotaxic Surgery-Arber Lab
By onThis protocol describes the steps for performing stereotaxic surgery in mice. It is applicable to intracranial injections (e.g. virus, drug) and placement of implants (e.g. optical fibers, electrode arrays) into targeted regions of mouse brains.
Immunohistochemistry & Microscopy-Falasconi & Kanodia et al 2025
By onImmunohistochemistry and microscopy methods used in Falasconi & Kanodia et al 2025.
AAV Production Protocol-Arber Lab
By onAAV Production methods used in Falasconi & Kanodia et al 2025 and is the general protocol for Arber Lab.
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER-lysosome contacts upon lysosome damage
By onGenetic studies link lysosome dysfunction to Parkinson's disease. VPS13C, a PD gene, relocates to damaged lysosomes, aiding in membrane repair. This process involves Rab7 and suggests early lipid transport as a protective response.
Immunostaining and Western blot images
By onRaw immunostaining and western blot images included in Adami et al, 2025.
CREsted: modeling genomic and synthetic cell type-specific enhancers across tissues and species
By onDeep learning models decode genomic regulatory codes well, especially enhancers. CREsted enables end-to-end enhancer modeling, design, and analysis, proving effective across datasets and species through comprehensive training and evaluation.
Tissue Isolation of the Region Around Locus Coeruleus for Single Nucleus RNA Profiling
By onIsolating tissue from the peri-locus coeruleus region in mice for single nucleus RNA
HyDrop v2: Scalable atlas construction for training sequence-to-function models
By onSingle-cell chromatin accessibility data helps train deep learning models to decode enhancer logic. HyDrop v2 improves data generation across species, organs, and diseases, delivering results comparable to commercial platforms like 10x Genomics.
Stereotaxic virus injection in the SNpc of rats
By onProtocol for stereotaxic virus injection in the substantia nigra pars compacta of rats
Optimized Stereotactic Injection Protocol for Targeting the Locus Coeruleus with Minimal Neurotoxicity
By onRefined stereotactic injection protocol targeting the Locus Coeruleus minimizes neurotoxicity.
Preparation of tissue punches of SNpc for the analyses of mitochondrial function
By onProtocol for the preparation of tissue punches of SNpc for the analyses of mitochondrial function
Preparation of midbrain slices for electrophysiology
By onProtocol for the preparation of midbrain slices for electrophysiology
Analyses of mitochondrial function in SNpc with the Seahorse XFe96
By onProtocol for analyses of mitochondrial function in SNpc with the Seahorse XFe96
Patch-clamp recordings of SNpc dopamine neurons from midbrain slices
By onProtocol for patch-clamp recordings of SNpc dopamine neurons from midbrain slices
WGS data related to “Is Gauchian genotyping of GBA1 variants reliable’
By onGauchian software helps identify GBA1 variants but struggles with rare ones due to database limitations, impacting diagnostic accuracy. Data from this study will aid future research on GBA1 variants.
