Image Processing and 3D Reconstruction – Chen et al. 2025 NSMB
By onImage processing and 3D reconstruction applied in Chen et al. 2025 NSMB
EMD-40735
By onStructure of human ULK1 complex core (2:2:2 stoichiometry) of the ATG13(450-517) mutant
Protocols for Goldman et al. 2025
By onAll protocols related to GEM-SCOPe and described in Glodman et al. 2025
all data related to “Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout”
By onRaw imaging data for "Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout"
Reply to: Is Gauchian genotyping of GBA1 variants reliable?
By onSummarizing a study by N. Tayebi et al. in Communications Biology, published in 2025.
Neuromelanin and selective neuronal vulnerability to Parkinson’s disease
By onNeuromelanine (NM), a pigment in human catecholamine neurons, plays a crucial role in PD. We review the development of NM in dopamine versus noradrenaline neurons and focus on previously overlooked cellular organelles in NM format and function.
End-product inhibition of the LRRK2-counteracting PPM1H phosphatase
By onPPM1H phosphatase reverses Rab GTPase phosphorylation by LRRK2 in Parkinson's disease. PPM1H binds Rab8A and Rab10 at an allosteric site, inhibiting phosphatase activity. Targeting this site may offer a therapeutic strategy.
Dynamic basal ganglia output signals license and suppress forelimb movements-Datasets
By onThis repository contains the datasets and analysis files associated with the study by Falasconi, Kanodia, and Arber (2025).
Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice
By onVPS13 proteins facilitate lipid transfer at membrane contact sites. VPS13A and VPS13C double knockout causes embryonic death due to impaired erythropoiesis and innate immunity activation.
Characterizing Parkinson’s Disease Clinical and Biomarker Interactions in REM Sleep Behavior Disorder
By ona-syn SAA positivity, DaT positivity, and hyposmia are highly associated with each other. MDS Prodromal PD Probability scores may be useful predictors of near-term progression, and thus as a stratification factor in clinical research study design
Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson′s Disease
By onWe investigated the role of inflammation in the pathogenesis of prodromal PD performing single-cell RNAseq analysis of CSF and blood from 111 individuals.
Article: PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection
By onPINK1 KO mice show PD-like symptoms post intestinal infections, with myeloid cells dysregulation and T cell response early after infection. PINK1 plays a key role in gut immune functions linked to early PD mechanisms.
Supporting data for “PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection”
By onData associated with “PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection”
