Source Data and protocols for White, et al 2025- The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract
By onThe manuscript investigates pyrethroid toxicity in enteroendocrine cells and the gastrointestinal tract. It includes source data, statistical output, qPCR gene expression analysis, RNAseq analysis, Metascape pathway analysis, and key resources.
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development (Preprint)
By onHominoid-specific L1 retrotransposons are expressed in human stem cells and organoids. Silencing L1s leads to changes in neural differentiation and organoid size, suggesting L1 involvement in central nervous system development.
Data associated with “Structural pathway for PI 3-kinase regulation by VPS15 in autophagy”
By onAll data from the manuscript "Structural pathway for PI 3-kinase regulation by VPS15 in autophagy" All figures can be reproduced from the files in this zenodo upload.
Immunohistochemistry (Histology + Imaging)-Mendelsohn et al 2025
By onThe protocol outlines the steps for preparing mouse brain tissue for immunostaining and imaging from Mendelsohn et al 2025.
In Situ Hybridization -Mendelsohn et al 2025
By onThis protocol outlines the steps for preparing mouse brain tissue for In Situ Hybridization from Mendelsohn et al 2025.
(x6) GBA heterozygous and homozygous mutant fibroblast lines available to share
By onCell lines deposited at ATCC used in a publication (10.1093/hmg/ddac233) include UCL-CTRL001, UCL-CTRL002, UCL-CTRL003, UCL-YCTRL001, UCL-E001K, UCL-N001S, and UCL-N002S, each with specific RRIDs.
EMD-48233
By onPI3KC3-C1 bound to RAB1A. Local refinement of Bara like domains of BECN1 and ATG14, and VPS15 WD40 domain
EMD-48259
By onPI3KC3-C1 bound to RAB1A. Consensus inactive state refinement of particle subset with strongest kinase domain density
EMD-48260
By onPI3KC3-C1 bound to RAB1A. Local refinement of VPS34KD in the inactive state, particle subset
EMD-48272
By onPI3KC3-C1 bound to RAB1A. VPS34 kinase domain in the active conformation, consensus reconstruction
9MHG
By onCryo EM reconstruction of PI3KC3-C1 in complex with Human RAB1A(Q70L), VPS34 kinase domain in the inactive conformation
