LRRK2 phosphorylation of Rab GTPases in Parkinson’s disease
By onReview: This paper highlights new findings related to LRRK2-mediated phosphorylation of Rab GTPases and their consequences.
Cell viability assessment
By onThis is the protocol for assessing cell viability using a MTS cell proliferation assay kit.
Diabetes and neuroaxonal damage in Parkinson’s disease
By onOur findings affirm Uyar et al's report of an association between PD-DM and more severe neuroaxonal damage. T2DM and PD share several pathological processes, in par mediated by hyperglycemia and possibly diabetic neuropathy.
Midbrain-like Organoids generation from hiPSCs
By onProtocol for generating midbrain organoids from human iPSCs.
pCAG-OSF-ATG13 (2-197)-R153D
By onPlasmid: Expresses human ATG13 HORMA R153D mutant in mammalian cells.
Surgical procedures for simultaneous optogenetic manipulation in the SNc and acute fiber photometry in the dorsal striatum
By onThis protocol describes the three surgical procedures required for simultaneous optogenetic stimulation in the Substantia Nigra pars compacta (SNc) and acute fiber photometry in the dorsal striatum.
HeLa culture, transfection, and labeling of Halo-fusion proteins
By onProtocol for HeLa culture, transfection, and labelling of Halo-fusion proteins.
Single-cell transcriptomic and proteomic analysis of Parkinson’s disease Brains
By onThis article established a single-nucleus transcriptomic profile of the prefrontal cortex from postmortem human brains of six patients with PD and six age-matched controls.
Synaptic Location Is a Determinant of the Detrimental Effects of α-Synuclein Pathology to Glutamatergic Transmission in the Basolateral Amygdala
By onStudy explores α-synuclein's impact on amygdala in Parkinson's. Aggregation affects cortico-BLA transmission, linked to psychiatric deficits in PD.
Isolation of NeuN+ cells from brain tissue (for CUT and RUN)
By onThis protocol describes the steps to isolate NeuN+ cells from brain tissue in preparation for CUT and RUN.
Essential surgeries for the electrophysiological recording from a behaving non-human primate brain 2 (Craniotomy)
By onProtocol for performing a craniotomy in a recording chamber on a cranial implant in nonhuman primates.
Data set of the manuscript “Neuronal hyperactivity-induced oxidant stress promotes in vivo a-synuclein brain spreading”
By onData set of the manuscript "Neuronal hyperactivity-induced oxidant stress promotes in vivo a-synuclein brain spreading."
pCAG-GST-ATG101-W110D/F112D
By onPlasmid: Expresses human ATG101 HORMA W110D/F112D mutant in mammalian cells.
CURTAIN—A unique web-based tool for exploration and sharing of MS-based proteomics data
By onLinks can also be reported in publications allowing readers to further survey the reported data. The authors discuss benefits for the research community of publishing proteomic data containing a shareable web-link.
Cx3cr1-cre;Ercc1-/fl mice
By onMicroglia may experience higher levels of DNA damage and potential senescence due to internal factors.
