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In Silico analysis links the NSL complex to Parkinson’s disease and the mitochondria – Protein-protein interaction data to functional enrichment analysis

By Katie Kelly, Patrick Lewis, Helene Plun-Favreau, Claudia Manzoni
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Output Details

Description
This bioinformatics approach has been taken to investigate the interactome of the NSL complex, to unpick its relevance to PD progression. The mitochondrial interactome of the NSL complex has been built, mining 3 separate repositories: PINOT, HIPPIE and MIST, for curated, literature-derived protein-protein interaction (PPI) data.
Identifier (DOI)
10.17504/protocols.io.5qpvorb19v4o/v1
Tags
  • Bioinformatics
  • GWAS
  • LRRK2
  • Mitochondria
  • PD progression
  • VPS35
Discovery Team
Team Hardy
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

  • User avatar fallback logo

    Katie Kelly

    External Collaborator

  • User avatar fallback logo

    Patrick Lewis

    External Collaborator

  • User avatar fallback logo

    Helene Plun-Favreau

    External Collaborator

  • User avatar fallback logo

    Claudia Manzoni

    External Collaborator

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Aligning Science Across Parkinson's
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