pCAG-OSF-ATG13 (2-197)-R153D
By onPlasmid: Expresses human ATG13 HORMA R153D mutant in mammalian cells.
Diabetes and neuroaxonal damage in Parkinson’s disease
By onOur findings affirm Uyar et al's report of an association between PD-DM and more severe neuroaxonal damage. T2DM and PD share several pathological processes, in par mediated by hyperglycemia and possibly diabetic neuropathy.
Essential surgeries for the electrophysiological recording from a behaving non-human primate brain 2 (Craniotomy)
By onProtocol for performing a craniotomy in a recording chamber on a cranial implant in nonhuman primates.
Isolation of NeuN+ cells from brain tissue (for CUT and RUN)
By onThis protocol describes the steps to isolate NeuN+ cells from brain tissue in preparation for CUT and RUN.
Synaptic Location Is a Determinant of the Detrimental Effects of α-Synuclein Pathology to Glutamatergic Transmission in the Basolateral Amygdala
By onStudy explores α-synuclein's impact on amygdala in Parkinson's. Aggregation affects cortico-BLA transmission, linked to psychiatric deficits in PD.
Passaging of feeder-free hPSCs
By onThis protocol describes the process of passaging human pluripotent stem cells (hPSCs) for feeder-free culturing of hPSCs using Accutase or ReLeSF.
fMRI tasks to explore emotion-motor interactions
By onCode for fMRI tasks designed to explore emotion-motor interactions—Active Escape and Approach-Avoidance tasks in the Socal Kinesia and Incentivization for Parkinson's Disease (SKIP) dataset.
Assay for Dual Rab GTPase binding to the LRRK2 Armadillo Domain
By onThe LRRK2 Armadillo domain contains multiple Rab GTPase binding sites. This assay shows that the sites can be occupied simultaneously.
CURTAIN—A unique web-based tool for exploration and sharing of MS-based proteomics data
By onLinks can also be reported in publications allowing readers to further survey the reported data. The authors discuss benefits for the research community of publishing proteomic data containing a shareable web-link.
pCAG-GST-ATG101-W110D/F112D
By onPlasmid: Expresses human ATG101 HORMA W110D/F112D mutant in mammalian cells.
Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and Arf6 GTPase disrupts the axonal transport of autophagosomes
By onThe authors found that LRRK2-hyperphosphorylated RABs disrupt the axonal transport of autophagosomes by perturbing the coordinated regulation of cytoplasmic dynein and kinesin motors.
Data set of the manuscript “Neuronal hyperactivity-induced oxidant stress promotes in vivo a-synuclein brain spreading”
By onData set of the manuscript "Neuronal hyperactivity-induced oxidant stress promotes in vivo a-synuclein brain spreading."
