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PINK1 and Parkin: unlocking a mitochondrial quality control pathway linked to Parkinson’s disease
onThis review focuses on understanding the PINK1/Parkin-mediated mitochondrial quality control pathway through the lens of abherrant immune activation as a driver of dopaminerigic neuron loss following the loss of PINK and Parkin.
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Rodent models based on endolysosomal genes involved in Parkinson’s disease
onThis review summarizes parkinsonian phenotypes in rodent models targeting genes that have a role in endolysosomal pathways and future steps to better understand the contribution of endolysosomal dysfunction to PD.
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Lysosomal dysfunction in neurodegeneration: emerging concepts and methods
onThis review summarizes key technological advances that have led to a better understanding of the contribution of the lysosome to neurodegeneration and highlights key questions to be addressed moving forward.
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The lysosome as a master regulator of iron metabolism
onThis review focuses on the role that the lysosome plays in maintaining iron homeostasis and how lysosomal iron dysregulation contributes to disease.
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Western blot protocol for detecting ATP10B in mouse/rat brain
onThis protocol describes the procedure for detection of ATP10B in rat and mouse brain tissue by Western blotting
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