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Primary data associated with doi: 10.7554/eLife.67900 (Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain)
onImmunofluorescence microscopy images, raw immunoblotting data and tabular data used to generate graphs shown in all figures.
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Primary data associated with doi: 10.15252/embr.202152675 (Structural basis for the specificity of PPM1H phosphatase for Rab GTPases. EMBO Rep. 2021 Nov 4;22(11):e52675)
onRaw immunoblotting data; Scans of Coomassie-stained SDS-PAGE gels; Tabular data for quantifications; List of cross-links with distances; Numerical data for in vitro assays; Data files from Astra Software analysis.
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Mass spectrometry proteomic data supporting the PPM1H/Rab8A crosslinking study described in doi: 10.15252/embr.202152675
onMass spectrometry proteomic data supporting the PPM1H/Rab8A crosslinking study described in doi: 10.15252/embr.202152675, deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD026367
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cDNA clone for bacterial expression of human PPM1H H153D
onPlasmid for bacterial expression of human PPM1H (H153D); contains TEV protease site for removal of 6His tag.
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Rapid fluctuations in functional connectivity of cortical networks encode spontaneous behavior
onPreprint: The authors develop a novel approach for deriving the time-varying functional connectivity of cortical networks and show this information encodes rapid fluctuations in behavioral state.
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Endoplasmic Reticulum Membrane Contact Sites, Lipid Transport, and Neurodegeneration
onReview: Several mutations of genes that encode proteins localized at the endoplasmic reticulum membrane contact sites result in familial neurodegenerative diseases. Here, the authors provide an overview of such diseases, with a specific focus on proteins that directly or indirectly impact lipid transport.
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Neuronal hyperactivity–induced oxidant stress promotes in vivo α-synuclein brain spreading
onPublished: This study investigated the relationship between neuronal activity and interneuronal transfer of α-synuclein, a Parkinson-associated protein, and elucidated mechanisms underlying this relationship.
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Genetic variations in GBA1 and LRRK2 genes: Biochemical and clinical consequences in Parkinson disease
onReview: This review compares GBA1 and LRRK2-associated PD, and highlights possible genotype-phenotype associations for GBA1 and LRRK2 separately, based on biochemical consequences of single variants.
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“LRRK2 phosphorylation of Rab GTPases in Parkinson’s disease”
onReview: This paper highlights new findings related to LRRK2-mediated phosphorylation of Rab GTPases and their consequences.
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Python script used to generate the heatmap representation of identified LRRK1 phosphosites reported in doi: 10.1042/BCJ20220308
onPython script used to generate the heatmap representation of identified high-confident LRRK1 phosphosites reported in doi: 10.1042/BCJ20220308. It contains the data used for analysis as well as the necessary FASTA sequences for mapping of phosphosite positions on peptides to the original protein sequence.
