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Global Parkinson’s Genetics Program Data Release 12
onIn July 2026, GP2 announced the 12th data release on the Terra and the Verily® Workbench platforms in collaboration with AMP® PDRD. This release includes 21,156 additional genotyped participants and 25,046 additional whole genome sequencing (WGS) participants. - The genotype array (NeuroBooster Array ) data, including locality-restricted samples, now consists of a total of 124,942 genotyped participants (64,228 PD cases, 34,925 Controls, and 25,789 “Other” phenotypes). - The WGS data now consists of a total of 63,272 sequenced participants (37,106 PD cases, 17,404 Controls, and 8,762 Other phenotypes). - The clinical exome data consists of 14,648 samples with PD. - Of the 147,451 unique samples with genetic data (NBA, WGS, or clinical exome), 53,869 individuals also have additional extended clinical information. Please see the accompanying blog for further description of this release. To obtain data access, please see https://amp-pd.org/researchers/data-use-agreement. For any publications using data from this release, please reference the DOI number and the following statement: "Data (DOI 10.5281/zenodo.20932193, release 12) and/or code used in the preparation of this article were obtained from Global Parkinson’s Genetics Program (GP2). GP2 is funded by the Aligning Science Across Parkinson’s (ASAP) initiative and implemented by The Michael J. Fox Foundation for Parkinson’s Research (https://gp2.org). For a complete list of GP2 members see https://gp2.org."
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Rotarod with Photometry
onThis protocol describes collecting in vivo fiber photometry data during rotarod behavior
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Ex Vivo Mouse Brain Slice Whole-Cell Patch-Clamp Electrophysiology – Lerner Lab
onThis protocol outlines steps for performing ex vivo slice whole-cell patch-clamp electrophysiology experiments, including optogenetic stimulation introduced through viral injection or transgenic expression.
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Stereotaxic Surgery for Viral Injections or Brain Implant
onThis protocol details stereotaxic surgery for injection of AAVs or implantation of fiber photometry probe(s) in mouse brain.
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Transcardial Perfusion for Immunohistochemistry
onThis protocol details transcardial perfusion of mice with PBS followed by 4% Paraformaldehyde
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Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum
onThalamic input can trigger dopamine release in the striatum during motor learning, likely reflecting action vigor rather than motor error. Changes in this mode of dopamine release may contribute to motor and non-motor symptoms of PD.
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Dataset for Article “Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum”
onThis is the primary dataset for the article by Miller-Hansen et al "Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum"
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Code for Miller-Hansen article “Thalamus orchestrates local acetylcholine-dependent dopamine release in the learning striatum”
onThis is the code generated by Miller-Hansen for analyzing output from Guppy.
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Pavlovian protocol – Fushiki et al 2024
onPavlovian Conditioning Protocols for Mouse Behavioral Studies Derived from Fushiki et al 2024.
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Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin
onStructural studies of the Parkinson's protein VPS13C provide a molecular basis for understanding its function and regulation.