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A 4-5X expansion microscopy protocol for high‑resolution imaging of olfactory sensory neuron cilia in mouse olfactory epithelium
onProtocol for expanding mouse olfactory epithelium for improved imaging: OE dissected on a cold platform, embedded in hydrogel, and expanded 4-5 times with ExM. Enables detailed visualization of ciliary structures without super-resolution microscopy.
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Selective loss of Primary Cilia and Neurotrophic Signaling in G51D α-Synuclein Mice Highlights a Common Pathway to Parkinson’s Disease
onG51D α-synuclein mice mimic disease symptoms, showing cilia loss in specific neurons and impaired neurotrophic signaling, contributing to disease progression. This highlights the role of ciliary dysfunction in Parkinson’s.
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Cardiac-sympathetic state predicts action restraint, gated by demonstrated agency
onIn healthy humans, beat-to-beat cardiac contractility during incentivized reaching predicts action restraint. Cardiac-sympathetic outflow flexibly shapes speed–accuracy tradeoffs under reward and loss contexts, beyond simple action mobilization.
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A RAB7A Phosphoswitch Coordinates Rubicon Homology Protein Regulation of PINK1/Parkin-Dependent Mitophagy
onPublished: Structural and functional data support a model in which the TBK1-dependent phosphorylation of RAB7A serves as a switch, promoting mitophagy by relieving Rubicon inhibition and favoring Pacer activation. View original preprint.
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Adult-specific Reelin expression alters striatal neuronal organization: implications for neuropsychiatric disorders
onReelin levels might modulate the numbers of striatal interneurons and the density of the nigrostriatal dopaminergic projections, suggesting that these changes may be involved in the protection of Reelin against neuropsychiatric disorders.
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EXPRESSION AND PURIFICATION OF HUMAN NEMO (GST-GFP-NEMO)
onThis protocol describes how to express and purify human NEMO (IKK-γ) tagged N-terminally with GST and EGFP.
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A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex
onA data-driven molecular map of the DLPFC reveals distinct spatial domains and cell populations, offering insights into neuropsychiatric disorders. The study provides a roadmap for implementing spatial clustering approaches in the human brain.
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A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice
onWhat should Parkinson's Disease patients eat? This study shows that dietary fiber impacts gut microbes and immune cells in the brain of a mouse model of Parkinson's.
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