Acute Slice Preparation

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Description

To better understand LRRK2 effects on intrinsic iSPNs adaptations, Drd2-eGFP BAC reporter mice were injected with haloperidol, haloperidol + MLi-2, or vehicle controls for 14 days. Then, we performed whole-cell current-clamp recordings on identified iSPNs in ex vivo striatal slices.

Identifier (DOI)

10.17504/protocols.io.e6nvw1879lmk/v1

Tags

Postmortem

Team

Team Awatramani

Program

Collaborative Research Network

Theme

Circuitry and Brain-Body Interactions

Meet the Authors

Chuyu Chen, PhD

Key Personnel: Team Awatramani,

Northwestern University
Loukia Parisiadou, PhD

Co-PI (Core Leadership): Team Awatramani,

Northwestern University (Chicago)

Acute Slice Preparation

Output Details

Meet the Authors

Chuyu Chen, PhD

Loukia Parisiadou, PhD

Related Research

Perfusion and Histology Rodrigues-Vaz and Athalye et al, 2025

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