Alpha-synuclein aggregates trigger anti-viral immune pathways and RNA editing in human astrocytes

This repository contains analysis code for the publication found here, which explored the response of astrocytes, neurons and astro-neuronal co-cultures to alpha-synuclein oligomers. The analysis includes work shared between two repositories: This current repository contains single cell and bulk RNA-sequencing analysis of the cell culture models utilised in the study. The repository at https://github.com/aaronwagen/Astrocytes_editing contains the analysis of RNA editing in the cell culture models, as well as in a published dataset of post-mortem brain samples.