Clinical data associated with doi.org/10.1038/s41531-025-01063-3

Severe GBA1 variants drive the GBA-PD clinical phenotype: implications for counselling and clinical trials

Variants in the GBA1 gene are common genetic risk factors for Parkinson's disease. A study compared clinical phenotypes in GBA-PD and idiopathic PD patients, finding that only severe GBA-PD cases show a more severe clinical profile.

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Bolen CosMx human Colon RNA and Protein code

Repository for the paper "Spatial single-cell multiomics..." includes CosMx assays, README files with scripts/data for analysis, and computational environment requirements. It also features a tissue microarray image showing morphology markers.

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Multi-omics reveal critical differentiation target for Parkinson’s Disease-vulnerable midbrain dopaminergic neurons

We describe a multiomic-guided strategy that enriches SOX6+ mDA neurons by combining enhancing Sonic Hedgehog agonism with prolonged Wnt activation. This work is a reproducible differentiation platform for generating the PD-susceptible mDA subtype

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Clinical data associated with doi.org/10.1038/s41531-025-01063-3

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Severe GBA1 variants drive the GBA-PD clinical phenotype: implications for counselling and clinical trials

Bolen CosMx human Colon RNA and Protein code

Multi-omics reveal critical differentiation target for Parkinson’s Disease-vulnerable midbrain dopaminergic neurons