Key Personnel: Team Hurley,
Max F. Perutz Laboratories
Published: Structural and functional data support a model in which the TBK1-dependent phosphorylation of RAB7A serves as a switch, promoting mitophagy by relieving Rubicon inhibition and favoring Pacer activation. View original preprint.
HeLa cells with FBXO7/PARK15 deletion made by CRISPR/Cas9.
H9 ES cells modified with AAVS1-NGN2 and CRISPR-deleted FBXO7.
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