Protocol for isolating nuclei from brain tissue for single-cell ATAC assays like 10X Genomics Chromium Next GEM Single Cell ATAC Kit, HyDrop-ATAC, etc.
Protocol outlines DNA extraction from blood, quality control, SNP, and APOE genotyping. Adapted from PRoBaND SNP Genotyping and ApoE Genotyping Protocol by Malek et al. for Parkinson's Disease study.