huw-morris-lab/PDD_GWSS

By Raquel Real, PhD, Alejandro Martínez Carrasco, MSc and Huw Morris
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Output Details

Description
Code used in the analysis from the manuscript Real et al., Association between the LRP1B and APOE loci and the development of Parkinson’s disease dementia.
Identifier (DOI)
10.5281/zenodo.6535455
Tags
  • APOE (Apolipoprotein E)
  • LRP1B
  • Parkinson’s disease with dementia
  • Risk loci
Team
Team Hardy
Program
Collaborative Research Network
Theme
PD Functional Genomics

Meet the Authors

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    Raquel Real, PhD

    Key Personnel: Team Hardy, 

    University College London

  • Alejandro Martínez Carrasco, MSc

    Key Personnel: Team Hardy, 

    University College London

  • Huw Morris

    Collaborating PI: Team Hardy, 

    University College London

Related Research

Association between the LRP1B and APOE loci and the development of Parkinson’s disease dementia

Genetic analysis of 3,964 PD cases revealed APOE-ϵ4 allele and new loci as risk factors for PD dementia progression, implicating amyloid pathway in PDD development and potential for amyloid-targeting therapy.

View Article

SNP Genotyping and ApoE Genotyping

Protocol outlines DNA extraction from blood, quality control, SNP, and APOE genotyping. Adapted from PRoBaND SNP Genotyping and ApoE Genotyping Protocol by Malek et al. for Parkinson's Disease study.

View Protocol

Combining biomarkers for prognostic modelling of Parkinson’s disease

Parkinson's disease progression varies among patients. Predicting progression accurately is crucial for clinical trial selection. Blood biomarkers like serum NfL, along with genetic factors (GBA, APOE) can enhance prediction beyond age and phenotype.

View Article
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