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Key Resource Table: Molecular analysis of network vulnerability to α-synuclein pathology reveals PAKs as therapeutic targets for Parkinson’s disease

By Naman Vatsa, J Kate Brynildsen, Thomas Goralski, Kevin Kurgat, Lindsay Meyerdirk, Libby Breton, Daniella DeWeerd, Laura Brasseur, Lisa Turner, Katelyn Becker, Kristin L. Gallik, Christine Isaguirre, Ryan Sheldon, Danielle (Dani) Bassett, Michael Henderson, PhD
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Output Details

Description
Key resource table for Molecular analysis of network vulnerability to α-synuclein pathology reveals PAKs as therapeutic targets for Parkinson’s disease
Identifier (DOI)
10.5281/zenodo.22681170
Tags
  • Biochemistry
  • Human
  • in situ
  • In Vitro
  • In Vivo
  • Mass Spectrometry
  • Mouse
  • Spatial Transcriptomics
  • Surgical
Discovery Team
Team Biederer
Program
Collaborative Research Network
Theme
Circuitry and Brain-Body Interactions

Meet the Authors

  • User avatar fallback logo

    Naman Vatsa

    External Collaborator

  • User avatar fallback logo

    J Kate Brynildsen

    External Collaborator

  • User avatar fallback logo

    Thomas Goralski

    External Collaborator

  • User avatar fallback logo

    Kevin Kurgat

    External Collaborator

  • User avatar fallback logo

    Lindsay Meyerdirk

    External Collaborator

  • User avatar fallback logo

    Libby Breton

    External Collaborator

  • User avatar fallback logo

    Daniella DeWeerd

    External Collaborator

  • User avatar fallback logo

    Laura Brasseur

    External Collaborator

  • User avatar fallback logo

    Lisa Turner

    External Collaborator

  • User avatar fallback logo

    Katelyn Becker

    External Collaborator

  • User avatar fallback logo

    Kristin L. Gallik

    External Collaborator

  • User avatar fallback logo

    Christine Isaguirre

    External Collaborator

  • User avatar fallback logo

    Ryan Sheldon

    External Collaborator

  • User avatar fallback logo

    Danielle (Dani) Bassett

    External Collaborator

  • Michael Henderson, PhD

    Co-PI (Core Leadership): Team Biederer,  Team Lee, 

    Van Andel Institute

Related Research

Network analysis of α-synuclein pathology progression reveals p21-activated kinases as regulators of vulnerability

Misfolded α-synuclein accumulation in PD leads to pathogenic processes. We mapped α-synuclein pathology in mice to identify vulnerable regions and potential therapeutic targets, highlighting group II PAK inhibitors as promising for treating PD.

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Microscopy-based bead protein-protein interaction assay.

Protocol for microscopy-based bead protein-protein interaction assay using GST- or mCherry-tagged baits and fluorescently-tagged preys. Requires purified proteins, monitors interactions in equilibrium, and allows quantification of fluorescent signal.

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GUV assay

This protocol describes the preparation of GUVs for the reconstitution of LC3 lipidation reaction through the steps of PI3P production by PI3KC3-C1, WIPI2 recruitment and LC3 lipidation with PE. Screen reader support enabled.

View Protocol
View More Outputs
Aligning Science Across Parkinson's
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